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Per mezzo di convulsive states, dosage of NEMBUTAL Sodium Solution should be kept to a minimum to avoid compounding the depression which may follow convulsions. The injection must be made slowly with due regard to the time required for the drug to penetrate the blood-brain barrier.
Sodium valproate and valproic acid appear to decrease barbiturate metabolism; therefore, barbiturate blood levels should be monitored and appropriate dosage adjustments made as indicated.
Published animal studies demonstrate that the administration of anesthetic and sedation drugs that block NMDA receptors and/or potentiate GABA activity increase neuronal apoptosis Sopra the developing brain and result Sopra long-term cognitive deficits when used for longer than 3 hours. The clinical significance of these findings is not clear.
Potential for paradoxical excitement and/or euphoria, restlessness, or delirium Durante patients with severe pain. Barbiturates could mask important symptoms Durante patients with acute or chronic pain. Use with caution Per mezzo di such patients. Should not be used Sopra the presence of uncontrolled pain.
Pretreatment with or concurrent administration of phenobarbital may decrease the effect of estradiol by increasing its metabolism.
Status epilepticus: Pentobarbital can be administered Per refractory status epilepticus according to the AAN guidelines for convulsive status epileptics.
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Barbiturates are metabolized primarily by the read more hepatic microsomal enzyme system, and the metabolic products are excreted Per the urine, and less commonly, Con the feces. Approximately 25 to 50 percent of a frazione of aprobarbital or phenobarbital is eliminated unchanged Per the urine, whereas the amount of other barbiturates excreted unchanged in the urine is negligible.
This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.
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